By D. Testa (auth.), Prof. Dr. med. Carlo Aul, Prof. Dr. med. Wolfgang Schneider (eds.)
ISBN-10: 3540610510
ISBN-13: 9783540610519
ISBN-10: 3642604110
ISBN-13: 9783642604119
Interferons have been one of the first cytokines to be studied clinically in recombinant shape within the Nineteen Eighties, starting a brand new period of pharmacotherapy in inner drugs. even supposing initially found as antiviral ingredients, interferons have been quickly hired within the therapy of tumors because of their antiproliferative, differentiation-inducing, and immunomodulatory houses. It used to be proven that these hematopoietic neoplasias that have been tricky to regard with chemotherapy, akin to bushy mobilephone leukemia, replied good to interferon remedy. The plentiful info from 15 years of learning the importance of this healing procedure in hematooncology and different scientific disciplines impressively exhibit that development in drugs isn't the results of superb person investigations, yet quite effects from longterm scientific research.
These are just initial findings, in spite of the fact that, due to the fact nonetheless at the present time there are various questions open relating the scientific program of interferons - specifically their attainable cumulative impression together with different cytokines or cytostatic drugs.
In the current quantity, well known foreign authors replace the significance of interferons in a number of fields of inner medication, dermatology, and urology. The e-book additionally comprises an creation to the genetics of the interferon procedure. extra chapters speak about the variety of unintended effects of those ingredients and indicate attainable focuses for extra medical interferon research.
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Extra resources for Interferons: Biological Activities and Clinical Efficacy
Example text
Lau JYN, Davis GL, Kniffen J et al (1993) Significance of serum hepatitis C virus RNA levels in chronic hepatitis C. Lancet 341: 1501-1504 2]. Hagiwara H, Hayashi N, Mita E et al (1993) Quantitative analysis of hepatitis C virus RNA in serum during interferon alfa therapy. Gastroenterology 104: 877-883 28. Magrin S, Craxi A, Fabiano C et al (1994) Hepatitis C viremia in chronic liver disease: relationship to interferon-a or corticosteroid treatment. Hepatology 19: 273-279 29. Agnello V, Chung RT, Kaplan LM (1992) A role for hepatitis C virus infection in type II cryoglobulinemia.
It is as yet unknown which dose of interferon should be used for a long-term therapy. Therapeutic regimens with doses exceeding 5 million U given three times a week for more than 12 months would give rise to clinical problems and a considerable number of side effects. The selection of patients who are good candidates for interferon therapy is perhaps most important in the case of chronic hepatitis C in light of the poor overall long-term response rates. However, there are still many problems with the selection of patients.
Some of these autoimmune diseases and phenomena respond well to interferon therapy such as mixed cryoglobulinemia, whereas others such as autoimmune thyroiditis may be worsened or even induced by interferon therapy. The explanation for these discrepancies is still unclear. It has also been shown that interferon therapy may induce an autoimmune hepatitis in chronic HCV infection; however these cases are rare. Interferon therapy has recently been found to worsen lichen ruber planus which is often associated with chronic hepatitis C infection [33].
Interferons: Biological Activities and Clinical Efficacy by D. Testa (auth.), Prof. Dr. med. Carlo Aul, Prof. Dr. med. Wolfgang Schneider (eds.)
by Ronald
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