By J.M. Parry, C.F. Arlett
This selection of sixty nine papers investigates 'in vitro' metabolic activation arrangements for 2 particular pairs of chemical analogues, benzidine (BZD) with 4,4-diaminoterphenyl (DAT) and 4-dimethyl-aminoazobenzene (DAB) with 4-cyanodimethylaniline (CDA). The arrangements chosen have been uninduced rat liver (using rats of an identical pressure because the bioassay). Aroclor-induced rat liver, uninduced mouse liver (using an identical mouse pressure as utilized in the 'in vivo' cytogenetics assays), and uninduced fowl. the most important bulk of the assays defined within the research concerned using huge universal batches of those fifty nine arrangements. The examine used to be subsidized through the uk Environmental Mutagen Society (UKEMS) and may stand as a massive landmark in genetic toxicology.
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Additional resources for Comparative Genetic Toxicology: The Second UKEMS Collaborative Study
91. 92. 93. 94. 95. 96. 97. 98. 99. 100. 101. 102. 103. , Stoeckle, G. and Kunz, w. (1980). Correlations between primary effects of xenobiotics on liver cells in vitro and their mutagenicity and carcinogenicity in vivo. Short-term Test Syst. Detect Carcinog. Proc. Symp. E. D. (1981). Unscheduled DNA synthesis response of human fibroblasts, WI-38 cells, to 20 coded chemicals. Progr. Mutat. Res. , Hyman, J, and Leifer, Z, (1981). DNA polymerase deficient assay. Progr. Mutat. Res. A. and Katz, M. (1981).
103. , Stoeckle, G. and Kunz, w. (1980). Correlations between primary effects of xenobiotics on liver cells in vitro and their mutagenicity and carcinogenicity in vivo. Short-term Test Syst. Detect Carcinog. Proc. Symp. E. D. (1981). Unscheduled DNA synthesis response of human fibroblasts, WI-38 cells, to 20 coded chemicals. Progr. Mutat. Res. , Hyman, J, and Leifer, Z, (1981). DNA polymerase deficient assay. Progr. Mutat. Res. A. and Katz, M. (1981). Mutagenic activity of 41 compounds in the in vivo micronucleus assay.
1979). Variation in response in the adult rat liver epithelial cell/hypoxanthine-guanine phosphoribosyl transferase (ARL/HGPRTase) mutation assay with different metabolic activation-dependent carcinogens. Environ. Mutagen. C. (1981). Evaluation of some chemicals by the sperm morphology assay. Progr. Mutat. Res. 1: 718-722 A SuiVey of the Literature on BZD and DAB 117. 118. 119. 120. 121. 122. 123. 124. 125. 126. 127. 128. 129. 130. 131. N. A. (1978). Evaluation of 16 carcinogens in the rat using the micronucleus test.
Comparative Genetic Toxicology: The Second UKEMS Collaborative Study by J.M. Parry, C.F. Arlett