By Charles J. Dorman, G. Dougan, D. W. Holden, P. Williams
ISBN-10: 1848161611
ISBN-13: 9781848161610
ISBN-10: 1860942725
ISBN-13: 9781860942723
Pathogenic micro organism have detailed organic homes, which permit them to invade a bunch and reason affliction. The molecular bases of those organic homes are the determinants of pathogenicity, and the study ambitions are to acknowledge them, establish them chemically and relate their constitution to operate. so much of our current wisdom comes from stories with cultures in vitro. notwithstanding, there's a emerging curiosity in bacterial behaviour within the contaminated host and new equipment were built for learning it. This e-book describes these equipment and indicates how they, and a up to date surge in traditional experiences, are laying off mild at the actions of bacterial pathogens in vivo. It discusses bacterial and host elements that function in vivo to reason affliction, exhibiting how phenomena famous in vitro relate to behavior in vivo and, if proof of relevance isn't to be had now, indicating the way it can be received.
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Hall, R. , Mekalanos, J. , Taylor, R. K. & Levine, M. A. 1988 Toxin, toxin-coregulated pili and the toxR regulon are essential for Vibrio cholerae pathogenesis in humans. J. Exp. Med. 168, 1487-1492. Hooke, A. , Sordelli, D. , Cerquetti, H. C. & Vogt, A. J. 1985 Quantitative determination of bacterial replication in vivo. Infect. Immun. 49, 424-427. Hormaeche, C. E. 1980 The in vivo division and death rate of Salmonell typhimurium in the spleens of naturally resistant and susceptible mice measured by the superinfecting phage technique of Meynell.
Typhimurium were maximally expressed in vitro at an oxygen tension, osmolarity and pH likely to exist in the ileum (Bajaj et al. 1996). Conditions designed to mimic those of the intestine showed that two type III secretion genes of S. 0 (Leclerc et al. 1998). When S. typhi was grown at an osmolarity (300 mM NaCl) similar to that of the human intestine, production of flagellin and salmonella invasion proteins increased, and that of the surface Vi antigen, which prevents their secretion, was depressed (Arricau et al.
Warren, R. , Wylie, H. , Sadoff, J. C , Deal, C. D. & Cross, A. S. 1996 Sialylation lessens the infectivity of Neisseria gonorrhoeae MSIImkC. J. Infect. Dis. 173, 1422-1427. Schwan, W. , Coulter, S. , Ng, E. Y. , Langhorne, M. , Ritchie, H. , Brody, L. , Bayer, A. , Folger, K. R. & Stover, C. K. 1998 Identification and characterization of the P u t P proline permease that contributes to in vivo survival of Staphylococcus aureus in animal models. Infect. Immun. 66, 567-572. , Rietschel, E. T. & Lindner, B.
The Activities of Bacterial Pathogens in Vivo by Charles J. Dorman, G. Dougan, D. W. Holden, P. Williams
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